| Salarin the Twisted [] | 36 | 1/128 |
| Sandy Casket [] | 300 | Unknown |
| Sandy Casket [] | 150 | Common |
| Sandy Casket (red) [] | 150–300 | Unknown |
| Sandy Casket (red) [] | 150 | Common |
| Saradomin wizard [] | 51 | 3/128 |
| Saradomin wizard [] | 180 | 2/128 |
| Scarab mage [] | 37 | 1/128 |
| Secure Chest (nature runes) [{'content': 'Using an estimated rarity as not enough data has been submitted.', 'name': 'estimated'}] | 3–7 | 4/9 |
| Security casket (CS Week) [] | 150 | Common |
| Security casket (CS Week) [] | 300 | Unknown |
| Seething Pyrefiend [] | — | Always |
| Skeleton [] | 2 | 2/128 |
| Skeleton [] | 5 | 10/233 |
| Skeleton looter [] | 1–30 | 15/128 |
| Skeleton Mage [] | 2 | 2/128 |
| Skeleton (Unarmed) [] | 2 | 2/128 |
| Skoblin [] | 6 | 10/262 |
| Small lizard [] | 5 | 20/128 |
| Small lizard [] | 42 | 4/128 |
| Smoulders, the Revenger [] | 125 | Always |
| Soldier [] | 6 | 2/128 |
| Spectral attendant [] | 5 | 1/10 |
| Spectral cultivator [] | 5 | 1/10 |
| Spectral worshipper [] | 5 | 1/10 |
| Spellwisp [] | 5 | 3/128 |
| Spellwisp [] | 12 | 2/128 |
| Stinkears [] | 3–12 | 1/8 |
| Thief [] | 6 | 2/128 |
| TokHaar-Mej [] | 200 | 1/7 |
| Tower guard [] | 6 | 2/128 |
| Treasure turtle (Easy) [] | 150 | 1/29 |
| Treasure turtle (Medium) [] | 300 | 1/29 |
| Tyras guard [] | 37 | 1/128 |
| Tyras guard [] | 75 | 8/128 |
| TzHaar-Mej [{'content': 'Fire runes are always dropped with either air or earth runes.', 'name': 'elemental'}] | 10–40 | 18/101 |
| War priest of chaos (Normal mode) [] | 60–100 | 1/29 |
| War priest of chaos (Story mode) [] | 15–20 | 600/10,000 |
| War priestess of chaos (Normal mode) [] | 60–100 | 1/29 |
| War priestess of chaos (Story mode) [] | 15–20 | 600/10,000 |
| Warped bat [] | 6 | 10/255 |
| Warped cockroach [] | 1 | 10/140 |
| Warped fly [] | 3 | 10/198 |
| Warped rat [] | 5 | 10/232 |
| Waterfiend [] | 1–100 | Common |
| Wild Runes [] | — | Varies |
| Wise Old Man/Tasks [] | 1–25 | Common |
| Wizard [] | 5 | 3/128 |