| Dagannoth guardian [] | 1 | 1/910.2 |
| Dark beast [] | 1 | 8/128 |
| Dark wizard (The Zamorakian Undercity) (Story mode) [] | 1 | 200/10,000 |
| Dark wizard elder (Story mode) [] | 1 | 200/10,000 |
| Dark wizard master (Story mode) [] | 1 | 200/10,000 |
| Desert lizard [] | 1 | 1/546.1 |
| Desert strykewyrm [] | 1–4 | 1/359.1 |
| Divine Druid (Equilibrium League) (Equilibrium Leagues) [] | 3–7 | 1/23 |
| Divine herb patch III [] | 1 | Common |
| Donny the Lad [] | 1 | 1/364.1 |
| Dried zombie [] | 1 | 1/1,092.3 |
| Drunken man [] | 1 | 1/237.4 |
| Dust devil [] | 1 | 1/390.1 |
| Dwarf weed (Farming) [{'content': 'Number of yield obtained per successful action.', 'name': 'yield'}] | 1 | Always |
| Earth elemental (Normal) [] | 1 | 1/390.1 |
| Earth warrior [] | 1 | 1/390.1 |
| Earth warrior [] | 1 | 1/384, 3 rolls |
| Edimmu [] | 5 | 28/2,560 |
| Eduard [] | 1 | 1/10,922.7 |
| Elf warrior (Elf Camp) [] | 1 | 1/364.1 |
| Elf warrior (Lletya) [] | 1 | 1/364.1 |
| Elite Khazard guard [] | 1 | 1/1,219 |
| Enraged barbarian spirit [] | 1 | 1/1,049.6 |
| Exiled kalphite guardian [] | 1 | 1/147.6 |
| Exiled kalphite marauder [] | 1 | 1/147.6 |
| Exiled kalphite paragon [] | 1 | 1/546.1 |
| Exiled kalphite soldier [] | 1 | 1/546.1 |
| Experiment No.2 [] | 1 | 1/130 |
| Fallen champion [] | 1 | 1/1,058.1 |
| Farmer (Members) [] | 1 | 1/496.5 |
| Feral vampyre [] | 1 | 1/546.1 |
| Ferocious barbarian spirit [] | 1–2 | 1/546.1 |
| Fire elemental [] | 1 | 1/390.1 |
| Fire giant [] | 1 | 1/273.1 |
| Flesh Crawler [] | 1 | 1/121.9 |
| Freidir [] | 1 | 1/2,184.5 |
| Freygerd [] | 1 | 1/2,184.5 |
| Frog [] | 1 | 1/546.1 |
| Frost dragon [] | 1 | 1/136.5 |
| Fungal mage [] | 1 | 1/384 |
| Fungal rodent [] | 1 | 1/341.3 |
| Galina [] | 1 | 1/10,922.7 |
| General malpractitioner [] | 1 | 1/533.3 |
| Georgy [] | 1 | 1/10,922.7 |
| Ghost (Spirit of Summer) [] | 1 | 1/546.1, 2 rolls |
| Giant ant worker [] | 1 | 1/1,092.3 |
| Giant dashing kebbit [] | 4–10 | Unknown |
| Giant diseased kebbit (In an encounter) [] | 3–7 | Unknown |