| Ulthven necromancer (Normal mode) [] | 10–20 | 1/227 |
| Unbreakable TzekHaar-Ket [{'content': 'Drop rate improved by 1% with tier 4 luck.', 'name': 't4luck'}] | 4–8 | 1/50 |
| Unbreakable TzekHaar-Ket [{'content': 'Drop rate improved by 1% with tier 4 luck.', 'name': 't4luck'}] | 30–50 | 1/33.33 |
| Undead Witch (Normal mode) [] | 1–11 | 1/116 |
| Undead Witch (Normal mode) [] | 10–20 | 1/227 |
| Verak Lith (Normal mode) [] | 10–14 | 1/114 |
| Verak Lith (Normal mode) [] | 1–5 | 1/58 |
| Verak Lith (Normal mode (Duo)) [{'content': 'Rolled if the codex and lore book drops fail.'}] | 10–19 | 950/1,000 |
| Verak Lith (Normal mode (Solo)) [{'content': 'Rolled if the codex and lore book drops fail.'}] | 10–30 | 925/1,000 |
| Verak Lith (Normal mode (Trio)) [{'content': 'Rolled if the codex and lore book drops fail.'}] | 10 | 958/1,000 |
| Verak Little (Normal mode) [] | 10–14 | 1/114 |
| Verak Little (Normal mode) [] | 1–5 | 1/58 |
| Vermyx, Brood Mother (Hard mode) [] | 54–66 | 40/1,000, 4 rolls |
| Vermyx, Brood Mother (Normal mode) [] | 54–66 | 40/1,000, 2 rolls |
| Volatile TzekHaar-Hur [{'content': 'Drop rate improved by 1% with tier 4 luck.', 'name': 't4luck'}] | 3 | 1/250 |
| Volatile TzekHaar-Hur [{'content': 'Drop rate improved by 1% with tier 4 luck.', 'name': 't4luck'}] | 4–8 | 1/40 |
| Volatile TzekHaar-Hur [{'content': 'Drop rate improved by 1% with tier 4 luck.', 'name': 't4luck'}] | 30–50 | 1/66.67 |
| War priest of chaos (Normal mode) [] | 16–40 | 1/227 |
| War priest of chaos (Story mode) [] | 16–40 | 1/455 |
| War priestess of chaos (Normal mode) [] | 16–40 | 1/227 |
| War priestess of chaos (Story mode) [] | 16–40 | 1/455 |
| Warding Magic Tentacle [{'content': 'Drop rate improved by 1% with tier 4 luck.', 'name': 't4luck'}] | 3 | 1/62.5 |
| Warding Magic Tentacle [{'content': 'Drop rate improved by 1% with tier 4 luck.', 'name': 't4luck'}] | 4–8 | 1/100 |
| Waterfiend (Normal mode) [] | 1–5 | 1/465.1 |
| Waterfiend (Normal mode) [] | 10–14 | 1/10,000 |
| Waterfiend [] | 16–40 | 1/227 |
| Xiang the Water-shaper (Normal mode) [] | 1–5 | 1/58.1 |
| Xiang the Water-shaper (Normal mode) [] | 10–14 | 1/1,250 |
| Yor'Ger the Deceiver (Normal mode) [] | 1–11 | 1/16 |
| Yor'Ger the Deceiver (Normal mode) [] | 10–20 | 1/30 |
| Yukimura of Hanto (Normal mode) [] | 1–5 | 1/58.1 |
| Yukimura of Hanto (Normal mode) [] | 10–14 | 1/1,250 |
| Zamorakian cultist (Normal mode) [] | 16–40 | 1/227 |
| Zamorakian cultist (Story mode) [] | 16–40 | 1/455 |
| Zamorakian hound master (Normal mode) [] | 16–40 | 1/227 |
| Zamorakian hound master (Story mode) [] | 16–40 | 1/455 |
| Zamorakian hunter (Normal mode) [] | 16–40 | 1/227 |
| Zamorakian hunter (Story mode) [] | 16–40 | 1/455 |
| Zamorakian ritual keeper (Level 107 (Normal mode)) [] | 16–40 | 1/227 |
| Zamorakian ritual keeper (Level 107 (Story mode)) [] | 16–40 | 1/455 |
| Zamorakian ritual keeper (Level 115 (Normal mode)) [] | 16–40 | 1/227 |
| Zamorakian ritual keeper (Level 115 (Story mode)) [] | 16–40 | 1/455 |
| Zanaris Market trinket stall [] | 1 | 1/20 |
| Zemouregal & Vorkath loot (hard) [] | 60–90 | 20/1,000, 8 rolls |
| Zemouregal & Vorkath loot (normal) [] | 17–25 | 15/1,000, 4 rolls |
| Zemouregal & Vorkath loot (story) [] | 17–25 | 15/1,000 |
| Zombie (Normal mode) [] | 1–11 | 1/116 |
| Zombie (Normal mode) [] | 10–20 | 1/227 |