| Sarkhan the Serpentspeaker (Normal mode) [] | 1 | 1/2,000 |
| Scabaras lancer [] | 1 | 4/128 |
| Scabaras mage [] | 1 | 4/128 |
| Scabaras ranger [] | 1 | 4/128 |
| Sea crocodile (Normal mode) [] | 1 | 1/142.9 |
| Sea horror (Normal mode (Section 1)) [] | 1 | 1/133.4 |
| Sea horror (Normal mode (Section 2)) [] | 1 | 1/19.06 |
| Seiryu the Azure Serpent (Normal mode) [] | 1 | 1/2,000 |
| Shrine Maiden Elei (Normal mode) [] | 1 | 1/28.57 |
| Shul the Molten (Normal mode) [] | 1 | 1/200 |
| Smoulders (Normal mode) [] | 1 | 1/200 |
| Spyndra (Normal mode) [] | 1 | 1/200 |
| Squeal of Fortune/Rewards/Limited [{'content': 'These items discontinued from the Squeal of Fortune are still obtainable in-game.', 'name': 'Neptune'}] | 50 | Discontinued |
| Swarm [] | 1 | Varies |
| Swordfish pool [] | 2 | Always |
| Taraket the Necromancer (Normal mode) [] | 1 | 1/28.57 |
| The Ambassador (Normal mode) [] | 1 | 1/28.57 |
| The Sanctum Guardian (Normal mode) [] | 1 | 1/2,000 |
| The Violet Lotus (Normal mode) [] | 1 | 1/2,000 |
| Tombi, Khan of Thalassia (Normal mode) [] | 1 | 1/28.57 |
| Ulthven Keith (Normal mode) [] | 1 | 1/28.57 |
| Ulthven necromancer (Normal mode (Floor 1)) [] | 1 | 1/142.9 |
| Ulthven necromancer (Normal mode (Floor 2)) [] | 1 | 1/20.41 |
| Undead Witch (Normal mode (Floor 1)) [] | 1 | 1/30.8 |
| Undead Witch (Normal mode (Floor 2)) [] | 1 | 1/4.4 |
| Undead Witch (Normal mode (Floor 3)) [] | 1 | 1/4.4 |
| Unspeakable horror [] | 8–12 | 10/128 |
| Unspeakable horror (elite) [] | 8–12 | 10/128, 3 rolls |
| Verak Lith (Normal mode) [] | 1 | 1/200 |
| Verak Little (Normal mode) [] | 1 | 1/200 |
| Waterfiend (Normal mode) [] | 1 | 1/400 |
| Xiang the Water-shaper (Normal mode) [] | 1 | 1/2,000 |
| Yor'Ger the Deceiver (Normal mode) [] | 1 | 1/28.57 |
| Yukimura of Hanto (Normal mode) [] | 1 | 1/2,000 |
| Zombie (The Shadow Reef) (Normal mode (Floor 1)) [] | 1 | 1/30.8 |
| Zombie (The Shadow Reef) (Normal mode (Floor 2)) [] | 1 | 1/4.4 |
| Zombie (The Shadow Reef) (Normal mode (Floor 3)) [] | 1 | 1/4.4 |