| Pyrefiend [] | 1 | 1/4,096 |
| Pyrefiend [] | 45–55 | 1/3,355,443.2 |
| Pyrefiend [] | 1 | 1/4,096 |
| Pyrefiend [] | 45–55 | 1/3,355,443.2 |
| Queen Black Dragon [] | 45–55 | 1/656.56 |
| Quetzathog (Normal mode) [] | 45–55 | 1/61,440 |
| Ranged Tentacle [{'content': 'Only dropped if tier 4 luck is not active.'}] | 4 | 1/100 |
| Raptor's chest of slaying [] | 10 | Always |
| Rare drop table (Free-to-play rare table) [] | 1 | 16/128 |
| Rare drop table (Gem table) [] | 1 | 2/128 |
| Rare drop table (Super rare table) [] | 45–55 | 25/640 |
| Rare gem rock [{'content': 'Available at Mining level 38. Chance increases with fewer gems available.'}] | 1 | 35/100 |
| Rathis [] | 45–55 | 1/61,440 |
| Ravenous ghoul [] | 1 | 1/4,096 |
| Ravenous ghoul [] | 45–55 | 1/3,355,443.2 |
| Red dragon [] | 1 | 1/1,638.4 |
| Red dragon [] | 45–55 | 1/1,342,177.28 |
| Red dragon (Dragonkin Laboratory) (Normal mode) [] | 45–55 | 1/61,440 |
| Reinforced chest (Dorgesh-Kaan) [] | 2–4 | Common |
| Renegade Menaphite soldier (Normal mode) [] | 45–55 | 1/61,440 |
| Rewards (Barbarian Assault) (Gamble points - high items) [] | 17 | Uncommon |
| Rewards (Barbarian Assault) (Gamble points - low items) [] | 5 | Common |
| Ripper Demon [] | 1 | 1/1,024 |
| Ripper Demon [] | 45–55 | 1/39,053.11 |
| Ripper dinosaur [] | 45–55 | 1/40,960 |
| Risen ghost [] | 3 | 10/100 |
| Rock [] | 1 | 1/1,638.4 |
| Rock [] | 45–55 | 1/1,342,177.28 |
| Rock crab [] | 1 | 1/8,192 |
| Rock crab [] | 45–55 | 1/6,710,886.4 |
| Rock golem [] | 1 | 1/4,096 |
| Rock golem [] | 45–55 | 1/3,355,443.2 |
| Rock lobster [] | 1 | 1/4,096 |
| Rock lobster [] | 45–55 | 1/3,355,443.2 |
| Rock slug [] | 1 | 1/2,048 |
| Rock slug [] | 45–55 | 1/1,677,721.6 |
| Rune dragon [] | 45–55 | 1/20,480 |
| Salarin the Twisted [] | 1 | 1/8,192 |
| Salarin the Twisted [] | 45–55 | 1/6,710,886.4 |
| Salawa akh [] | 1 | 10/128 |
| Salawa akh [] | 45–55 | 1/61,440 |
| Sangri the Red (Normal mode) [] | 45–55 | 1/61,440 |
| Sanguine crawler [] | 1 | 1/1,024 |
| Sanguine crawler [] | 45–55 | 1/838,860.8 |
| Sarcophagus (Jaldraocht Pyramid) [] | 1 | Rare |
| Sarkhan the Serpentspeaker (Normal mode) [] | 45–55 | 1/61,440 |
| Scabaras lancer [] | 1 | 1/585.14, 2 rolls |
| Scabaras lancer [] | 45–55 | 1/479,349.03, 2 rolls |