| Dagannoth (Lighthouse) [] | 45–55 | 1/6,710,886.4 |
| Dagannoth guardian [] | 1 | 1/1,024 |
| Dagannoth guardian [] | 45–55 | 1/838,860.8 |
| Dagannoth Prime [] | 1 | 1/1,024 |
| Dagannoth Prime [] | 45–55 | 1/57,247.1 |
| Dagannoth Rex [] | 1 | 1/1,024 |
| Dagannoth Rex [] | 45–55 | 1/57,247.1 |
| Dagannoth spawn [] | 1 | 1/8,192 |
| Dagannoth spawn [] | 45–55 | 1/6,710,886.4 |
| Dagannoth Supreme [] | 1 | 1/1,024 |
| Dagannoth Supreme [] | 45–55 | 1/57,247.1 |
| Dagannoth (Melee) [] | 1 | 1/8,192 |
| Dagannoth (Melee) [] | 45–55 | 1/6,710,886.4 |
| Dagannoth (Ranged) [] | 1 | 1/8,192 |
| Dagannoth (Ranged) [] | 45–55 | 1/6,710,886.4 |
| Dark beast [] | 45–55 | 1/81,920 |
| Dark beast [] | 45–55 | 1/40,960, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 45–55 | 1/61,440 |
| Dark wizard elder (Normal mode) [] | 45–55 | 1/61,440 |
| Dark wizard master (Normal mode) [] | 45–55 | 1/61,440 |
| Death Lotus rogue [] | 1 | 1/4,096 |
| Death Lotus rogue [] | 45–55 | 1/3,355,443.2 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 45–55 | 1/61,440 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 45–55 | 1/61,440 |
| Deathbreath (Normal mode) [] | 45–55 | 1/61,440 |
| Desert lizard [] | 1 | 1/1,638.4 |
| Desert lizard [] | 45–55 | 1/1,342,177.28 |
| Desert strykewyrm [] | 1 | 1/718.22 |
| Desert strykewyrm [] | 45–55 | 1/588,367.64 |
| Devil's snare [] | 45–55 | 1/40,960 |
| Donny the Lad [] | 1 | 1/4,096 |
| Donny the Lad [] | 45–55 | 1/3,355,443.2 |
| Dragon wolf alpha (Normal mode) [] | 45–55 | 1/61,440 |
| Dragonstone dragon [] | 45–55 | 1/61,440 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 1 | 76/1,000 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 45–55 | 1/61,440 |
| Dried zombie [] | 1 | 1/4,096 |
| Dried zombie [] | 45–55 | 1/3,355,443.2 |
 Dung kalphite[] | 1 | Rare |
| Dust devil [] | 1 | 1/4,096 |
| Dust devil [] | 45–55 | 1/3,355,443.2 |
| Dust devil [] | 1 | 1/640, 3 rolls |
| Dust devil [] | 45–55 | 1/524,288, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 1 | 1/8,192 |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 45–55 | 1/6,710,886.4 |
| Dwarf (Regular) [] | 1 | 1/8,192 |
| Dwarf (Regular) [] | 45–55 | 1/6,710,886.4 |
| Earth elemental [] | 1 | 1/4,096 |