| Sea Snake Hatchling [] | 1 | Always |
| Sea troll [] | 1 | Always |
| Seagull [] | 1 | Always |
| Secure chest (Dorgesh-Kaan) [] | 4–6 | Common |
| Seren archer [] | 1 | Always |
| Seren mage [] | 1 | Always |
| Seren warrior [] | 1 | Always |
| Sergeant Grimspike [] | 1 | Always |
| Sergeant Steelwill [] | 1 | Always |
| Sergeant Strongstack [] | 1 | Always |
| Sewer rat [] | 1 | Always |
| Shadow Hound [] | 1 | Always |
 Shady stranger (1)[] | 1 | Always |
| Shantay guard [] | 1 | Always |
 Shipyard worker[] | 1 | Always |
| Silverquill, the Dreadhog [] | 1 | 1/92 |
| Sir Hugo [] | 1 | Always |
| Sir Mordred [] | 1 | Always |
| Skeletal archer [] | 1 | Always |
| Skeletal hand [] | 1 | Always |
| Skeletal miner [] | 1 | Always |
| Skeletal sorcerer [] | 1 | Always |
| Skeletal warrior [] | 1 | Always |
| Skeleton (Ancient Cavern) [] | 1 | Common |
| Skeleton (Barrows) [] | 1 | Always |
| Skeleton (Dark Warriors' Fortress) [] | 1 | Always |
| Skeleton [] | 1 | Always |
| Skeleton [] | 1 | Always |
| Skeleton [] | 1 | Always |
| Skeleton (Melzar's Maze) [] | 1 | Always |
| Skeleton (Tarn's Lair) (High level) [] | 1 | Always |
| Skeleton (Tarn's Lair) (Low level) [] | 1 | Always |
| Skeleton (Tarn's Lair) (Medium level) [] | 1 | Always |
| Skeleton (Temple Trekking) [] | 1 | Always |
| Skeleton (Ullek) [] | 1 | Always |
| Skeleton (Uncharted Isles) [] | 1 | Always |
| Skeleton brute [] | 1 | Always |
| Skeleton fremennik [] | 1 | Always |
| Skeleton heavy [] | 1 | Always |
| Skeleton hero [] | 1 | Always |
| Skeleton looter [] | 1 | Always |
| Skeleton Mage [] | 1 | Always |
| Skeleton thug [] | 1 | Always |
| Skeleton warlock [] | 1 | Always |
| Skeleton warlord [] | 1 | Always |
| Skeleton (Armed) [] | 1 | Always |
| Skeleton (Unarmed) [] | 1 | Always |
| Skoblin [] | 1 | Always |