| Skoblin [] | 1 | Always |
| Skulls mercenary (Brainwashed) [] | 1 | Always |
| Small Forgotten Belongings [{'content': 'This drop is replaced by oddments for Ironman Mode players.', 'name': 'ironman'}] | 5 | 1,881/10,170, 3 rolls |
| Small lizard [] | 1 | Always |
| Small parcel [] | 10 | Common |
 Smashing Pumpkin (Normal)[] | 5 | 1,647/19,501 |
| Snake [] | 1 | Always |
| Snake [] | 1 | Always |
| Soldier [] | 1 | Always |
 Sorebones[] | 1 | Always |
| Soulless [] | 1 | Always |
| Sparkling glyph [] | 1 | Unknown |
| Specimen tray [] | 1 | Common |
| Speedy Keith [] | 1 | Always |
| Spidine [] | 1 | Always |
| Spotted kebbit [] | 1 | Always |
| Squiggles [] | 1 | Always |
| Stag [] | 1 | Always |
| Stag [] | 1 | Always |
| Starlight [] | 1 | Always |
| Stinkears [] | 1 | Always |
| Strawberry cow (player-owned farm teaser) [] | 1 | Always |
| Summoned Zombie [] | 1 | Always |
| Swamp frog [] | 1 | Always |
| Swarming turoth [] | 1 | Always |
| Swordchick [] | 1 | Always |
| Taraket the Necromancer (Normal mode) [] | 1 | Always |
| Taraket the Necromancer (Story mode) [] | 1 | Always |
| Tarik [] | 1 | Always |
| Tentacle [{'content': 'Typically not dropped in practice because the tentacles retreat at 1 LP.'}] | 4 | Always |
| Terror dog (Level 61) [] | 1 | Always |
| Terrorbird [] | 1 | Always |
| The Ambassador (Normal mode) [] | 1 | Always |
| The Ambassador (Story mode) [] | 1 | Always |
| The Kendal [] | 1 | Always |
| The Sanctum Guardian (Normal mode) [] | 1 | Always |
| The Sanctum Guardian (Story mode) [] | 1 | Always |
| Thief [] | 1 | Always |
| Thing under the bed [] | 1 | Always |
| Thora [] | 1 | Always |
| Thorhild [] | 1 | Always |
| Thug [] | 1 | Always |
| Tough Guy [] | 1 | Always |
| Tower guard [] | 1 | Always |
| Trade floor guard [] | 1 | Always |
| Trahaearn automaton mk III [] | 1 | Always |
| Trahaearn automaton mk IV [] | 1 | Always |
| Translator [] | 1 | Always |