| Cyclops (God Wars Dungeon) [] | 1 | 1/8,192,000 |
| Cyclossus [] | 1 | 1/256,000 |
| Dagannoth (Lighthouse) [] | 1 | 1/20,971,520 |
| Dagannoth guardian [] | 1 | 1/2,621,440 |
| Dagannoth Prime [] | 1 | 1/178,897.18 |
| Dagannoth Rex [] | 1 | 1/178,897.18 |
| Dagannoth spawn [] | 1 | 1/20,971,520 |
| Dagannoth Supreme [] | 1 | 1/178,897.18 |
| Dagannoth (Melee) [] | 1 | 1/20,971,520 |
| Dagannoth (Ranged) [] | 1 | 1/20,971,520 |
| Dark beast [] | 1 | 1/256,000 |
| Dark beast [] | 1 | 1/128,000, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 1 | 1/192,000 |
| Dark wizard elder (Normal mode) [] | 1 | 1/192,000 |
| Dark wizard master (Normal mode) [] | 1 | 1/192,000 |
| Death Lotus rogue [] | 1 | 1/10,485,760 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 1 | 1/192,000 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 1 | 1/192,000 |
| Deathbreath (Normal mode) [] | 1 | 1/192,000 |
| Desert lizard [] | 1 | 1/4,194,304 |
| Desert strykewyrm [] | 1 | 1/1,838,648.89 |
| Devil's snare [] | 1 | 1/128,000 |
| Donny the Lad [] | 1 | 1/10,485,760 |
| Dragon wolf alpha (Normal mode) [] | 1 | 1/192,000 |
| Dragonstone dragon [] | 1 | 1/192,000 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 1 | 1/192,000 |
| Dried zombie [] | 1 | 1/10,485,760 |
| Dust devil [] | 1 | 1/10,485,760 |
| Dust devil [] | 1 | 1/1,638,400, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 1 | 1/20,971,520 |
| Dwarf (Regular) [] | 1 | 1/20,971,520 |
| Earth elemental [] | 1 | 1/10,485,760 |
| Earth warrior [] | 1 | 1/10,485,760 |
| Earth warrior [] | 1 | 1/983,040, 3 rolls |
| Eastern mercenary (Normal mode) [] | 1 | 1/192,000 |
| Eastern soldier [] | 1 | 1/20,971,520 |
| Edimmu [] | 1 | 1/128,000 |
| Edimmu [] | 1 | 1/128,000 |
| Eduard [] | 1 | 1/83,886,080 |
| Elegorn the Celestial (Normal mode) [] | 1 | 1/192,000 |
| Elf warrior (Elf Camp) [] | 1 | 1/4,194,304 |
| Elf warrior (Lletya) [] | 1 | 1/4,194,304 |
| Elite Black Knight [] | 1 | 1/10,485,760 |
| Elite Dark Ranger [] | 1 | 1/20,971,520 |
| Elite Dark Warrior [] | 1 | 1/20,971,520 |
| Elite Khazard guard [] | 1 | 1/4,681,142.86 |
| Elite Profane Scabarite [] | 1 | 12/1,024 |
| Elite Profane Scabarite [] | 1 | 1/192,000 |