| Dagannoth Supreme [] | 45–55 | 1/143,117.74 |
| Dagannoth (Melee) [] | 45–55 | 1/16,777,216 |
| Dagannoth (Ranged) [] | 45–55 | 1/16,777,216 |
| Dark beast [] | 45–55 | 1/204,800 |
| Dark beast [] | 45–55 | 1/102,400, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 45–55 | 1/153,600 |
| Dark wizard elder (Normal mode) [] | 45–55 | 1/153,600 |
| Dark wizard master (Normal mode) [] | 45–55 | 1/153,600 |
| Death Lotus rogue [] | 45–55 | 1/8,388,608 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 45–55 | 1/153,600 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 45–55 | 1/153,600 |
| Deathbreath (Normal mode) [] | 45–55 | 1/153,600 |
| Desert lizard [] | 45–55 | 1/3,355,443.2 |
| Desert strykewyrm [] | 45–55 | 1/1,470,919.11 |
| Devil's snare [] | 45–55 | 1/102,400 |
| Donny the Lad [] | 45–55 | 1/8,388,608 |
| Dragon wolf alpha (Normal mode) [] | 45–55 | 1/153,600 |
| Dragonstone dragon [] | 1 | Always |
| Dragonstone dragon [] | 45–55 | 1/153,600 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 45–55 | 1/153,600 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode,Story mode) [] | 1 | Always |
| Dried zombie [] | 45–55 | 1/8,388,608 |
| Dust devil [] | 45–55 | 1/8,388,608 |
| Dust devil [] | 45–55 | 1/1,310,720, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 45–55 | 1/16,777,216 |
| Dwarf (Regular) [] | 45–55 | 1/16,777,216 |
| Earth elemental [] | 45–55 | 1/8,388,608 |
| Earth warrior [] | 45–55 | 1/8,388,608 |
| Earth warrior [] | 45–55 | 1/786,432, 3 rolls |
| Eastern mercenary (Normal mode) [] | 45–55 | 1/153,600 |
| Eastern soldier [] | 45–55 | 1/16,777,216 |
| Edimmu [] | 45–55 | 1/102,400 |
| Edimmu [] | 45–55 | 1/102,400 |
| Eduard [] | 45–55 | 1/67,108,864 |
| Elegorn the Celestial (Normal mode) [] | 45–55 | 1/153,600 |
| Elf warrior (Elf Camp) [] | 45–55 | 1/3,355,443.2 |
| Elf warrior (Lletya) [] | 45–55 | 1/3,355,443.2 |
| Elite Black Knight [] | 45–55 | 1/8,388,608 |
| Elite Dark Ranger [] | 45–55 | 1/16,777,216 |
| Elite Dark Warrior [] | 45–55 | 1/16,777,216 |
| Elite Khazard guard [] | 45–55 | 1/3,744,914.29 |
| Elite Profane Scabarite [] | 45–55 | 1/153,600 |
| Elite rune dragon [] | 45–55 | 1/10,240 |
| Elite Sakadagami (Normal mode) [] | 45–55 | 1/153,600 |
| Elite Sotapanna (Normal mode) [] | 45–55 | 1/153,600 |
| Emberbound Soul (Normal mode) [] | 45–55 | 1/153,600 |
| Engorged lava strykewyrm (Normal mode) [] | 45–55 | 1/153,600 |
| Enlightened Sotapanna (Normal mode) [] | 45–55 | 1/153,600 |