| Dagannoth spawn [] | 270–330 | 1/8,388,608 |
| Dagannoth Supreme [] | 270–330 | 1/71,558.87 |
| Dagannoth (Melee) [] | 270–330 | 1/8,388,608 |
| Dagannoth (Ranged) [] | 270–330 | 1/8,388,608 |
| Dark beast [] | 270–330 | 1/102,400 |
| Dark beast [] | 270–330 | 1/51,200, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 270–330 | 1/76,800 |
| Dark wizard elder (Normal mode) [] | 270–330 | 1/76,800 |
| Dark wizard master (Normal mode) [] | 270–330 | 1/76,800 |
| Death Lotus rogue [] | 270–330 | 1/4,194,304 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 270–330 | 1/76,800 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 270–330 | 1/76,800 |
| Deathbreath (Normal mode) [] | 270–330 | 1/76,800 |
| Desert lizard [] | 270–330 | 1/1,677,721.6 |
| Desert strykewyrm [] | 270–330 | 1/735,459.56 |
| Devil's snare [] | 270–330 | 1/51,200 |
| Donny the Lad [] | 270–330 | 1/4,194,304 |
| Dragon wolf alpha (Normal mode) [] | 270–330 | 1/76,800 |
| Dragonstone dragon [] | 270–330 | 1/76,800 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 270–330 | 1/76,800 |
| Dried zombie [] | 270–330 | 1/4,194,304 |
| Dust devil [] | 270–330 | 1/4,194,304 |
| Dust devil [] | 270–330 | 1/655,360, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 270–330 | 1/8,388,608 |
| Dwarf (Regular) [] | 270–330 | 1/8,388,608 |
| Earth elemental [] | 270–330 | 1/4,194,304 |
| Earth warrior [] | 270–330 | 1/4,194,304 |
| Earth warrior [] | 270–330 | 1/393,216, 3 rolls |
| Eastern mercenary (Normal mode) [] | 270–330 | 1/76,800 |
| Eastern soldier [] | 270–330 | 1/8,388,608 |
| Edimmu [] | 270–330 | 1/51,200 |
| Edimmu [] | 270–330 | 1/51,200 |
| Eduard [] | 270–330 | 1/33,554,432 |
| Elegorn the Celestial (Normal mode) [] | 270–330 | 1/76,800 |
| Elf warrior (Elf Camp) [] | 270–330 | 1/1,677,721.6 |
| Elf warrior (Lletya) [] | 270–330 | 1/1,677,721.6 |
| Elite Black Knight [] | 270–330 | 1/4,194,304 |
| Elite Dark Ranger [] | 270–330 | 1/8,388,608 |
| Elite Dark Warrior [] | 270–330 | 1/8,388,608 |
| Elite Khazard guard [] | 270–330 | 1/1,872,457.14 |
| Elite Profane Scabarite [] | 270–330 | 1/76,800 |
| Elite rune dragon [] | 270–330 | 1/5,120 |
| Elite Sakadagami (Normal mode) [] | 270–330 | 1/76,800 |
| Elite Sotapanna (Normal mode) [] | 270–330 | 1/76,800 |
| Emberbound Soul (Normal mode) [] | 270–330 | 1/76,800 |
| Engorged lava strykewyrm (Normal mode) [] | 270–330 | 1/76,800 |
| Enlightened Sotapanna (Normal mode) [] | 270–330 | 1/76,800 |
| Enraged barbarian spirit [] | 270–330 | 1/4,030,464 |