| Crocodile akh [] | 65–85 | 1/2,400 |
| Croesus (Active) [] | 120–180 | 50/1,000 |
| Crwys worker (Pickpocketing) [] | 1 | 4/128 |
 Crystal impling[] | 30 | 60/500 |
| Crystal impling jar [] | 30 | 60/500 |
| Crystal Shapeshifter (Magic) [] | 12 | 12/128 |
| Crystal Shapeshifter (Magic) [] | 65–85 | 1/2,400 |
| Cyclops [] | 65–85 | 1/102,400 |
| Cyclops [] | 65–85 | Very rare |
| Cyclops (God Wars Dungeon) [] | 65–85 | 1/102,400 |
| Cyclossus [] | 65–85 | 1/3,200 |
| Dagannoth (Lighthouse) [] | 65–85 | 1/262,144 |
| Dagannoth guardian [] | 65–85 | 1/32,768 |
| Dagannoth Prime [] | 65–85 | 1/2,236.21 |
| Dagannoth Rex [] | 65–85 | 1/2,236.21 |
| Dagannoth spawn [] | 65–85 | 1/262,144 |
| Dagannoth Supreme [] | 65–85 | 1/2,236.21 |
| Dagannoth (Melee) [] | 65–85 | 1/262,144 |
| Dagannoth (Ranged) [] | 65–85 | 1/262,144 |
| Dark beast [] | 65–85 | 1/3,200 |
| Dark beast [] | 65–85 | 1/1,600, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 65–85 | 1/2,400 |
| Dark wizard elder (Normal mode) [] | 65–85 | 1/2,400 |
| Dark wizard master (Normal mode) [] | 65–85 | 1/2,400 |
| Death Lotus rogue [] | 4–10 | 6/128 |
| Death Lotus rogue [] | 65–85 | 1/131,072 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 65–85 | 1/2,400 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 65–85 | 1/2,400 |
| Deathbreath (Normal mode) [] | 65–85 | 1/2,400 |
| Demon Boss (Wilderness) [] | 40 | 4/64, 5 rolls |
| Desert lizard [] | 65–85 | 1/52,428.8 |
| Desert strykewyrm [] | 65–85 | 1/22,983.11 |
| Devil's snare [] | 65–85 | 1/1,600 |
| Divine magic tree [] | 1 | Always |
| Donny the Lad [] | 65–85 | 1/131,072 |
| Dragon wolf alpha (Normal mode) [] | 65–85 | 1/2,400 |
| Dragonstone dragon [] | 65–85 | 1/2,400 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 65–85 | 1/2,400 |
| Dried zombie [] | 65–85 | 1/131,072 |
| Dust devil [] | 65–85 | 1/131,072 |
| Dust devil [] | 65–85 | 1/20,480, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 65–85 | 1/262,144 |
| Dwarf (Regular) [] | 65–85 | 1/262,144 |
| Earth elemental [] | 65–85 | 1/131,072 |
| Earth warrior [] | 65–85 | 1/131,072 |
| Earth warrior [] | 65–85 | 1/12,288, 3 rolls |
| Eastern mercenary (Normal mode) [] | 65–85 | 1/2,400 |
| Eastern soldier [] | 65–85 | 1/262,144 |