| Cyclops [] | 3–5 | Very rare |
| Cyclops (God Wars Dungeon) [] | 3–5 | 1/6,553,600 |
| Cyclossus [] | 3–5 | 1/204,800 |
| Dagannoth (Lighthouse) [] | 3–5 | 1/16,777,216 |
| Dagannoth guardian [] | 3–5 | 1/2,097,152 |
| Dagannoth Prime [] | 3–5 | 1/143,117.74 |
| Dagannoth Rex [] | 3–5 | 1/143,117.74 |
| Dagannoth spawn [] | 3–5 | 1/16,777,216 |
| Dagannoth Supreme [] | 3–5 | 1/143,117.74 |
| Dagannoth (Melee) [] | 3–5 | 1/16,777,216 |
| Dagannoth (Ranged) [] | 3–5 | 1/16,777,216 |
| Dark beast [] | 3–5 | 1/204,800 |
| Dark beast [] | 3–5 | 1/102,400, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 3–5 | 1/153,600 |
| Dark wizard elder (Normal mode) [] | 3–5 | 1/153,600 |
| Dark wizard master (Normal mode) [] | 3–5 | 1/153,600 |
| Death Lotus rogue [] | 3–5 | 1/8,388,608 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 3–5 | 1/153,600 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 3–5 | 1/153,600 |
| Deathbreath (Normal mode) [] | 3–5 | 1/153,600 |
| Desert lizard [] | 3–5 | 1/3,355,443.2 |
| Desert strykewyrm [] | 1 | 1/15,150 |
| Desert strykewyrm [] | 3–5 | 1/1,470,919.11 |
| Devil's snare [] | 3–5 | 1/102,400 |
| Donny the Lad [] | 3–5 | 1/8,388,608 |
 Dragon impling[] | 1 | 1/18 |
| Dragon impling jar [] | 1 | 1/18 |
| Dragon wolf alpha (Normal mode) [] | 3–5 | 1/153,600 |
| Dragonstone dragon [] | 3–5 | 1/153,600 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 3–5 | 1/153,600 |
| Dried zombie [] | 3–5 | 1/8,388,608 |
| Dust devil [] | 3–5 | 1/8,388,608 |
| Dust devil [] | 3–5 | 1/1,310,720, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 3–5 | 1/16,777,216 |
| Dwarf (Regular) [] | 3–5 | 1/16,777,216 |
| Earth elemental [] | 3–5 | 1/8,388,608 |
| Earth warrior [] | 3–5 | 1/8,388,608 |
| Earth warrior [] | 3–5 | 1/786,432, 3 rolls |
| Eastern mercenary (Normal mode) [] | 3–5 | 1/153,600 |
| Eastern soldier [] | 3–5 | 1/16,777,216 |
| Edimmu [] | 3–5 | 1/102,400 |
| Edimmu [] | 3–5 | 1/102,400 |
| Eduard [] | 3–5 | 1/67,108,864 |
| Elegorn the Celestial (Normal mode) [] | 3–5 | 1/153,600 |
| Elf warrior (Elf Camp) [] | 3–5 | 1/3,355,443.2 |
| Elf warrior (Lletya) [] | 3–5 | 1/3,355,443.2 |
| Elite Black Knight [] | 3–5 | 1/8,388,608 |
| Elite Dark Ranger [] | 3–5 | 1/16,777,216 |