| Dagannoth Prime [] | 5–8 | 1/57,247.1 |
| Dagannoth Rex [] | 5–8 | 1/57,247.1 |
| Dagannoth spawn [] | 5–8 | 1/6,710,886.4 |
| Dagannoth Supreme [] | 5–8 | 1/57,247.1 |
| Dagannoth (Melee) [] | 5–8 | 1/6,710,886.4 |
| Dagannoth (Ranged) [] | 5–8 | 1/6,710,886.4 |
| Dark beast [] | 5–8 | 1/81,920 |
| Dark beast [] | 5–8 | 1/40,960, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 5–8 | 1/61,440 |
| Dark wizard elder (Normal mode) [] | 5–8 | 1/61,440 |
| Dark wizard master (Normal mode) [] | 5–8 | 1/61,440 |
| Death Lotus rogue [] | 5–8 | 1/3,355,443.2 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 5–8 | 1/61,440 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 5–8 | 1/61,440 |
| Deathbreath (Normal mode) [] | 5–8 | 1/61,440 |
| Desert lizard [] | 5–8 | 1/1,342,177.28 |
| Desert strykewyrm [] | 5–8 | 1/588,367.64 |
| Devil's snare [] | 1 | 2/102 |
| Devil's snare [] | 5–8 | 1/40,960 |
| Donny the Lad [] | 5–8 | 1/3,355,443.2 |
| Dragon wolf alpha (Normal mode) [] | 5–8 | 1/61,440 |
| Dragonstone dragon [] | 5–8 | 1/61,440 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 5–8 | 1/61,440 |
| Dried zombie [] | 5–8 | 1/3,355,443.2 |
| Dust devil [] | 5–8 | 1/3,355,443.2 |
| Dust devil [] | 5–8 | 1/524,288, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 5–8 | 1/6,710,886.4 |
| Dwarf (Regular) [] | 5–8 | 1/6,710,886.4 |
| Earth elemental [] | 5–8 | 1/3,355,443.2 |
| Earth warrior [] | 5–8 | 1/3,355,443.2 |
| Earth warrior [] | 5–8 | 1/314,572.8, 3 rolls |
| Eastern mercenary (Normal mode) [] | 5–8 | 1/61,440 |
| Eastern soldier [] | 5–8 | 1/6,710,886.4 |
| Edimmu [] | 5–8 | 1/40,960 |
| Edimmu [] | 5–8 | 1/40,960 |
| Eduard [] | 5–8 | 1/26,843,545.6 |
| Elegorn the Celestial (Normal mode) [] | 5–8 | 1/61,440 |
| Elf warrior (Elf Camp) [] | 5–8 | 1/1,342,177.28 |
| Elf warrior (Lletya) [] | 5–8 | 1/1,342,177.28 |
| Elite Black Knight [] | 5–8 | 1/3,355,443.2 |
| Elite Dark Ranger [] | 5–8 | 1/6,710,886.4 |
| Elite Dark Warrior [] | 5–8 | 1/6,710,886.4 |
| Elite Khazard guard [] | 5–8 | 1/1,497,965.71 |
| Elite Profane Scabarite [] | 5–8 | 1/61,440 |
| Elite rune dragon [] | 5–8 | 1/4,096 |
| Elite Sakadagami (Normal mode) [] | 5–8 | 1/61,440 |
| Elite Sotapanna (Normal mode) [] | 5–8 | 1/61,440 |
| Emberbound Soul (Normal mode) [] | 5–8 | 1/61,440 |