| Dagannoth Prime [] | 45–55 | 1/4,472.43 |
| Dagannoth Rex [] | 45–55 | 1/4,472.43 |
| Dagannoth spawn [] | 45–55 | 1/524,288 |
| Dagannoth Supreme [] | 45–55 | 1/4,472.43 |
| Dagannoth (Melee) [] | 45–55 | 1/524,288 |
| Dagannoth (Ranged) [] | 45–55 | 1/524,288 |
| Dark beast [] | 45–55 | 1/6,400 |
| Dark beast [] | 45–55 | 1/3,200, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 45–55 | 1/4,800 |
| Dark wizard elder (Normal mode) [] | 45–55 | 1/4,800 |
| Dark wizard master (Normal mode) [] | 45–55 | 1/4,800 |
| Death Lotus rogue [] | 45–55 | 1/262,144 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 45–55 | 1/4,800 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 45–55 | 1/4,800 |
| Deathbreath (Normal mode) [] | 45–55 | 1/4,800 |
| Desert lizard [] | 45–55 | 1/104,857.6 |
| Desert strykewyrm [] | 45–55 | 1/45,966.22 |
| Devil's snare [] | 45–55 | 1/3,200 |
| Donny the Lad [] | 45–55 | 1/262,144 |
| Dragon wolf alpha (Normal mode) [] | 45–55 | 1/4,800 |
| Dragonstone dragon [] | 45–55 | 1/4,800 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 45–55 | 1/4,800 |
| Dried zombie [] | 45–55 | 1/262,144 |
| Dust devil [] | 45–55 | 1/262,144 |
| Dust devil [] | 45–55 | 1/40,960, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 45–55 | 1/524,288 |
| Dwarf (Regular) [] | 45–55 | 1/524,288 |
| Earth elemental [] | 45–55 | 1/262,144 |
| Earth warrior [] | 45–55 | 1/262,144 |
| Earth warrior [] | 45–55 | 1/24,576, 3 rolls |
| Eastern mercenary (Normal mode) [] | 45–55 | 1/4,800 |
| Eastern soldier [] | 45–55 | 1/524,288 |
| Edimmu [] | 45–55 | 1/3,200 |
| Edimmu [] | 45–55 | 1/3,200 |
| Eduard [] | 45–55 | 1/2,097,152 |
| Elegorn the Celestial (Normal mode) [] | 45–55 | 1/4,800 |
| Elf warrior (Elf Camp) [] | 45–55 | 1/104,857.6 |
| Elf warrior (Lletya) [] | 45–55 | 1/104,857.6 |
| Elite Black Knight [] | 45–55 | 1/262,144 |
| Elite Dark Ranger [] | 45–55 | 1/524,288 |
| Elite Dark Warrior [] | 45–55 | 1/524,288 |
| Elite Khazard guard [] | 45–55 | 1/117,028.57 |
| Elite Profane Scabarite [] | 45–55 | 1/4,800 |
| Elite rune dragon [] | 45–55 | 1/320 |
| Elite Sakadagami (Normal mode) [] | 45–55 | 1/4,800 |
| Elite Sotapanna (Normal mode) [] | 45–55 | 1/4,800 |
| Emberbound Soul (Normal mode) [] | 45–55 | 1/4,800 |
| Engorged lava strykewyrm (Normal mode) [] | 45–55 | 1/4,800 |