| Crawling hand [] | 675–825 | 1/4,194,304 |
| Crocodile akh [] | 675–825 | 1/76,800 |
| Crwys worker (Pickpocketing) [] | 1 | 12/128 |
| Crystal Shapeshifter (Magic) [] | 675–825 | 1/76,800 |
| Cyclops [] | 675–825 | 1/3,276,800 |
| Cyclops [] | 675–825 | Very rare |
| Cyclops (God Wars Dungeon) [] | 675–825 | 1/3,276,800 |
| Cyclossus [] | 675–825 | 1/102,400 |
| Dagannoth (Lighthouse) [] | 675–825 | 1/8,388,608 |
| Dagannoth guardian [] | 675–825 | 1/1,048,576 |
| Dagannoth Prime [] | 675–825 | 1/71,558.87 |
| Dagannoth Rex [] | 675–825 | 1/71,558.87 |
| Dagannoth spawn [] | 675–825 | 1/8,388,608 |
| Dagannoth Supreme [] | 675–825 | 1/71,558.87 |
| Dagannoth (Melee) [] | 675–825 | 1/8,388,608 |
| Dagannoth (Ranged) [] | 675–825 | 1/8,388,608 |
| Dark beast [] | 675–825 | 1/102,400 |
| Dark beast [] | 675–825 | 1/51,200, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 675–825 | 1/76,800 |
| Dark wizard elder (Normal mode) [] | 675–825 | 1/76,800 |
| Dark wizard master (Normal mode) [] | 675–825 | 1/76,800 |
| Death Lotus rogue [] | 675–825 | 1/4,194,304 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 675–825 | 1/76,800 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 675–825 | 1/76,800 |
| Deathbreath (Normal mode) [] | 675–825 | 1/76,800 |
| Demon Boss (Non-Wilderness) [] | 60 | 5/64, 5 rolls |
| Desert lizard [] | 675–825 | 1/1,677,721.6 |
| Desert strykewyrm [] | 675–825 | 1/735,459.56 |
| Devil's snare [] | 675–825 | 1/51,200 |
| Divine yew tree [] | 1 | Always |
| Donny the Lad [] | 675–825 | 1/4,194,304 |
| Dragon wolf alpha (Normal mode) [] | 675–825 | 1/76,800 |
| Dragonstone dragon [] | 675–825 | 1/76,800 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 675–825 | 1/76,800 |
| Dried zombie [] | 675–825 | 1/4,194,304 |
| Dust devil [] | 675–825 | 1/4,194,304 |
| Dust devil [] | 675–825 | 1/655,360, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 675–825 | 1/8,388,608 |
| Dwarf (Regular) [] | 675–825 | 1/8,388,608 |
| Earth elemental [] | 675–825 | 1/4,194,304 |
| Earth warrior [] | 675–825 | 1/4,194,304 |
| Earth warrior [] | 675–825 | 1/393,216, 3 rolls |
| Eastern mercenary (Normal mode) [] | 675–825 | 1/76,800 |
| Eastern soldier [] | 675–825 | 1/8,388,608 |
| Edimmu [] | 675–825 | 1/51,200 |
| Edimmu [] | 675–825 | 1/51,200 |
| Eduard [] | 675–825 | 1/33,554,432 |
| Elegorn the Celestial (Normal mode) [] | 675–825 | 1/76,800 |