| Crocodile akh [] | 180–220 | 1/192,000 |
| Crystal Shapeshifter (Magic) [] | 2 | 8/128 |
| Crystal Shapeshifter (Magic) [] | 180–220 | 1/192,000 |
| Cyclops [] | 180–220 | 1/8,192,000 |
| Cyclops [] | 180–220 | Very rare |
| Cyclops (God Wars Dungeon) [] | 180–220 | 1/8,192,000 |
| Cyclossus [] | 180–220 | 1/256,000 |
| Dagannoth (Lighthouse) [] | 180–220 | 1/20,971,520 |
| Dagannoth guardian [] | 180–220 | 1/2,621,440 |
| Dagannoth Prime [] | 180–220 | 1/178,897.18 |
| Dagannoth Rex [] | 180–220 | 1/178,897.18 |
| Dagannoth spawn [] | 180–220 | 1/20,971,520 |
| Dagannoth Supreme [] | 180–220 | 1/178,897.18 |
| Dagannoth (Melee) [] | 180–220 | 1/20,971,520 |
| Dagannoth (Ranged) [] | 180–220 | 1/20,971,520 |
| Dark beast [] | 180–220 | 1/256,000 |
| Dark beast [] | 180–220 | 1/128,000, 3 rolls |
| Dark wizard (The Zamorakian Undercity) (Normal mode) [] | 180–220 | 1/192,000 |
| Dark wizard elder (Normal mode) [] | 180–220 | 1/192,000 |
| Dark wizard master (Normal mode) [] | 180–220 | 1/192,000 |
| Darkmeyer magic stall [] | 2–4 | 84/1,200 |
| Death Lotus rogue [] | 180–220 | 1/10,485,760 |
| Death Lotus rogue (Elite Dungeons) (Temple of Aminishi (Normal mode)) [] | 180–220 | 1/192,000 |
| Death Lotus rogue (Elite Dungeons) (The Shadow Reef (Normal mode)) [] | 180–220 | 1/192,000 |
| Deathbreath (Normal mode) [] | 180–220 | 1/192,000 |
| Desert lizard [] | 180–220 | 1/4,194,304 |
| Desert strykewyrm [] | 180–220 | 1/1,838,648.89 |
| Devil's snare [] | 180–220 | 1/128,000 |
| Donny the Lad [] | 180–220 | 1/10,485,760 |
| Dragon wolf alpha (Normal mode) [] | 180–220 | 1/192,000 |
| Dragonstone dragon [] | 180–220 | 1/192,000 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 180–220 | 1/192,000 |
| Dried zombie [] | 180–220 | 1/10,485,760 |
| Dust devil [] | 180–220 | 1/10,485,760 |
| Dust devil [] | 180–220 | 1/1,638,400, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 180–220 | 1/20,971,520 |
| Dwarf (Regular) [] | 180–220 | 1/20,971,520 |
| Earth elemental [] | 180–220 | 1/10,485,760 |
| Earth warrior [] | 180–220 | 1/10,485,760 |
| Earth warrior [] | 180–220 | 1/983,040, 3 rolls |
| Eastern mercenary (Normal mode) [] | 180–220 | 1/192,000 |
| Eastern soldier [] | 180–220 | 1/20,971,520 |
 Eclectic impling[] | 1 | 1/100 |
| Eclectic impling jar [] | 1 | 1/100 |
| Edimmu [] | 180–220 | 1/128,000 |
| Edimmu [] | 180–220 | 1/128,000 |
| Eduard [] | 180–220 | 1/83,886,080 |
| Elder Trove (Bik, T1) [] | 20 | 40/1,000 |