| Dragonstone dragon [] | 450–550 | 1/192,000 |
| Dragonstone dragon (Dragonkin Laboratory) (Normal mode) [] | 450–550 | 1/192,000 |
| Dried zombie [] | 450–550 | 1/10,485,760 |
| Dust devil [] | 5 | 4/128 |
| Dust devil [] | 450–550 | 1/10,485,760 |
| Dust devil [] | 25 | 2/40, 3 rolls |
| Dust devil [] | 450–550 | 1/1,638,400, 3 rolls |
| Dwarf (Keldagrim and White Wolf Mountain) [] | 450–550 | 1/20,971,520 |
| Dwarf (Regular) [] | 450–550 | 1/20,971,520 |
| Earth elemental [] | 450–550 | 1/10,485,760 |
| Earth warrior [] | 450–550 | 1/10,485,760 |
| Earth warrior [] | 450–550 | 1/983,040, 3 rolls |
| Eastern mercenary (Normal mode) [] | 450–550 | 1/192,000 |
| Eastern soldier [] | 450–550 | 1/20,971,520 |
| Edimmu [] | 450–550 | 1/128,000 |
| Edimmu [] | 450–550 | 1/128,000 |
| Eduard [] | 450–550 | 1/83,886,080 |
| Elder Trove (Bik, T3) [] | 40 | 40/1,000 |
| Elder Trove (Ful, T3) [] | 40 | 40/1,000 |
| Elder Trove (Jas, T3) [] | 40 | 40/1,000 |
| Elder Trove (Wen, T3) [] | 40 | 40/1,000 |
| Elegorn the Celestial (Normal mode) [] | 450–550 | 1/192,000 |
| Elf warrior (Elf Camp) [] | 450–550 | 1/4,194,304 |
| Elf warrior (Lletya) [] | 450–550 | 1/4,194,304 |
| Elite Black Knight [] | 450–550 | 1/10,485,760 |
| Elite Dark Mage [] | 1–4 | 2/128 |
| Elite Dark Ranger [] | 450–550 | 1/20,971,520 |
| Elite Dark Warrior [] | 450–550 | 1/20,971,520 |
| Elite Khazard guard [] | 450–550 | 1/4,681,142.86 |
| Elite Profane Scabarite [] | 450–550 | 1/192,000 |
| Elite rune dragon [] | 450–550 | 1/12,800 |
| Elite Sakadagami (Normal mode) [] | 450–550 | 1/192,000 |
| Elite Sotapanna (Normal mode) [] | 450–550 | 1/192,000 |
| Emberbound Soul (Normal mode) [] | 450–550 | 1/192,000 |
| Engorged lava strykewyrm (Normal mode) [] | 450–550 | 1/192,000 |
| Enlightened Sotapanna (Normal mode) [] | 450–550 | 1/192,000 |
| Enraged barbarian spirit [] | 450–550 | 1/10,076,160 |
| Transmutation (Equilibrium League) [{'content': 'Requires appropriate material to transmute from.'}] | 1–10 | Special |
 Essence impling[] | 11 | 1/100 |
| Essence impling jar [] | 11 | 1/100 |
| Exiled kalphite guardian [] | 450–550 | 1/3,495,253.33 |
| Exiled kalphite guardian [] | 450–550 | 1/256,000 |
| Exiled kalphite marauder [] | 450–550 | 1/3,495,253.33 |
| Exiled kalphite marauder [] | 450–550 | 1/256,000 |
| Exiled kalphite paragon [] | 450–550 | 1/4,194,304 |
| Exiled Kalphite Queen [] | 450–550 | 1/120,636.91, 4 rolls |
| Exiled kalphite soldier [] | 450–550 | 1/4,194,304 |
| Experiment No.2 [] | 450–550 | 1/3,495,253.33 |